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"Jessie" follows an 18 year old girl, Jessie (Debby Ryan), as she moves to New York City to become a nanny for the wealthy Ross family, which includes children Emma, Zuri, Luke, and Ravi. While watching the kids, she must also keep track of the family's 7 foot lizard, Mr. Kippling. Though the children are rambunctious, Jessie learns to love them and give them the support and attention they deserve.